Measuring Type 1/Type 2 Immunity

  • Helms, T., B.O. Boehm, R. J. Assad, R.T. Trezza, P.V. Lehmann, and M. Tary-Lehmann. 2000. Direct visualization of cytokine-producing, recall antigen-specific CD4 memory T cells in healthy individuals and HIV patients. J. Immunol. 164: 3723-3732.
  • Forsthuber, T., H.C. Yip, and P.V. Lehmann. 1996. Induction of TH1 and TH2 immunity in neonatal mice. Science. 271: 1728-1730.
  • Chu, R.S., O.S. Targoni, A.M. Krieg, P.V. Lehmann, and C.V. Harding. 1997. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J. Exp. Med. 186: 1623-1631.
  • Yip, H.C., A.Y. Karulin, M. Tary-Lehmann, M.D. Hesse, H. Radeke, P. Heeger, R.T. Trezza, F.P. Heinzel, T. Forsthuber, and P.V. Lehmann. 1999. Adjuvant guided type 1 and type 2 immunity: Infectious/non-infectious dichotomy defines the class of response. J. Immunol. 162: 3942-3949.
  • Karulin, A.Y., M.D. Hesse, H.C. Yip, and P.V. Lehmann. 2002. Indirect IL-4 pathway in Th1 immunity. J. Immunol. 168: 545-553.
  • Guerkov, R.E., O.S. Targoni, C.R. Kreher, B.O. Boehm, M.T. Herrera, M. Tary-Lehmann, P.V. Lehmann, and S.K. Schwander. 2003. Detection of low-frequency antigen-specific IL-10-producing CD4(+) T cells via ELISPOT in PBMC: cognate vs. nonspecific production of the cytokine. J. Immunol. Methods. 279: 111-121.
  • Kleen, T. O., S. Kadereit, L. R. Fanning, J. Jaroscak, P. Fu, H. J. Meyerson, L. Kulchycki, L. F. Slivka, M. Kozik, M. Tary-Lehmann, and M. J. Laughlin. 2005. Recipient-specific tolerance after HLA-mismatched umbilical cord blood stem cell transplantation. Transplantation 80:1316.
  • Ott, P. A., B. A. Herzog, S. Quast, H. H. Hofstetter, B. O. Boehm, M. Tary-Lehmann, I. Durinovic-Bello, B. R. Berner, and P. V. Lehmann. 2005. Islet-cell antigen-reactive T cells show different expansion rates and Th1/Th2 differentiation in type 1 diabetic patients and healthy controls. Clin. Immunol. 115:102.
  • Eisenberg, J. C., S. J. Czinn, C. A. Garhart, R. W. Redline, W. C. Bartholomae, J. M. Gottwein, J. G. Nedrud, S. E. Emancipator, B. B. Boehm, P. V. Lehmann, and T. G. Blanchard. 2003. Protective efficacy of anti-Helicobacter pylori immunity following systemic immunization of neonatal mice. Infect. Immun. 71:1820.
  • Radeke, H. H., T. Tschernig, A. Karulin, G. Schumm, S. N. Emancipator, K. Resch, and M. Tary-Lehmann. 2002. CD4+ T cells recognizing specific antigen deposited in glomeruli cause glomerulonephritis-like kidney injury. Clin. Immunol. 104:161.
  • Helms, T., B. O. Boehm, R. J. Asaad, R. P. Trezza, P. V. Lehmann, and M. Tary-Lehmann. 2000. Direct visualization of cytokine-producing recall antigen-specific CD4 memory T cells in healthy individuals and HIV patients. J. Immunol. 164:3723.
  • Karulin, A. Y., M. D. Hesse, M. Tary-Lehmann, and P. V. Lehmann. 2000. Single-cytokine-producing CD4 memory cells predominate in type 1 and type 2 immunity. J. Immunol. 164:1862.
  • Tary-Lehmann, M., D. E. Hricik, A. C. Justice, N. S. Potter, and P. S. Heeger. 1998. Enzyme-linked immunosorbent assay spot detection of interferon-gamma and interleukin 5-producing cells as a predictive marker for renal allograft failure. Transplantation 66:219.
  • Lehmann, P. V., D. Matesic, G. Benichou, and P. S. Heeger. 1997. Induction of T helper 2 immunity to an immunodominant allopeptide. Transplantation 64:292.
  • Tian, J., P. V. Lehmann, and D. L. Kaufman. 1997. Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens. J. Exp. Med. 186:2039.
  • Chu, R. S., O. S. Targoni, A. M. Krieg, P. V. Lehmann, and C. V. Harding. 1997. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J. Exp. Med. 186:1623.