Determinant Mapping/High Throughput Screening

  • Targoni, O.S. and P.V. Lehmann. 1998. Endogenous myelin basic protein inactivates the high avidity T cell repertoire. J. Exp. Med. 187: 2055-2063.
  • Yip, H.C., A.Y. Karulin, M. Tary-Lehmann, M.D. Hesse, H. Radeke, P. Heeger, R.T. Trezza, F.P. Heinzel, T. Forsthuber, and P.V. Lehmann. 1999. Adjuvant guided type 1 and type 2 immunity: Infectious/ non-infectious dichotomy defines the class of response. J. Immunol. 162: 3942-3949.
  • Heeger, P.S., A. Valujskikh, and P.V. Lehmann. 2000. Comprehensive assessment of determinant specificity, frequency, and cytokine signature of the primed CD8 cell repertoire induced by a minor transplantation antigen. J. Immunol. 165: 1278-1284.
  • Pelfrey, C.M., R.A. Rudick, A.C. Cotleur, J.C. Lee, M. Tary-Lehmann, and P.V. Lehmann. 2000. Quantification of self-recognition in multiple sclerosis by single-cell analysis of cytokine production. J. Immunol. 165: 1641-1651.
  • Anthony, D.D., and P.V. Lehmann. 2003. T-cell epitope mapping using the ELISPOT approach. Methods. 29: 260-269.
  • Anthony, D. D., H. Valdez, A. B. Post, N. L. Carlson, P. S. Heeger, and P. V. Lehmann. 2002. Comprehensive determinant mapping of the hepatitis C-specific CD8 cell repertoire reveals unpredicted immune hierarchy. Clin. Immunol. 103:264.
  • Moldovan, I.R., Rudick, R.A., Cotleur, A.C., Born S.E., Lee, J.C., Karafa, M.T., Pelfrey, C.M. Longitudinal single-cell cytokine responses reveal recurrent autoimmune myelin reactivity in relapsing-remitting multiple sclerosis patients. Mult Scler. 2005 Jun;11(3):251-60. <abstract>
  • Pelfrey C. M., Moldovan I. R., Epitope mapping in multiple sclerosis using the ELISPOT assay. Methods Mol Biol. 2005;302:219-36. <abstract>
  • Moldovan, I.R., Rudick, R.A., Cotleur, A.C., Born S.E., Lee, J.C., Karafa, M.T., Pelfrey, C.M. Interferon gamma responses to myelin peptides in multiple sclerosis correlate with a new clinical measure of disease progression. J Neuroimmunol. 2003 Aug;141(1-2):132-40. <abstract>