Autoimmunity

  • Bhardwaj, V., V. Kumar, I. S. Grewal, T. Dao, P. V. Lehmann, H. M. Geysen, and E. E. Sercarz. 1994. T cell determinant structure of myelin basic protein in B10.PL, SJL/J, and their F1S. J. Immunol. 152:3711. <abstract>
  • Birnbaum, G., L. Kotilinek, S. D. Miller, C. S. Raine, Y. L. Gao, P. V. Lehmann, and R. S. Gupta. 1998. Heat shock proteins and experimental autoimmune encephalomyelitis. II: environmental infection and extra-neuraxial inflammation alter the course of chronic relapsing encephalomyelitis. J. Neuroimmunol. 90:149. <abstract>
  • Darabi, K., A. Y. Karulin, B. O. Boehm, H. H. Hofstetter, Z. Fabry, J. C. LaManna, J. C. Chavez, M. Tary-Lehmann, and P. V. Lehmann. 2004. The third signal in T cell-mediated autoimmune disease? J. Immunol. 173:92. <abstract>
  • Falcioni, F., Z. Dembic, S. Muller, P. V. Lehmann, and Z. A. Nagy. 1990. Flexibility of the T cell repertoire. Self tolerance causes a shift of T cell receptor gene usage in response to insulin. J. Exp. Med. 171:1665. <abstract>
  • Gross, D. M., T. Forsthuber, M. Tary-Lehmann, C. Etling, K. Ito, Z. A. Nagy, J. A. Field, A. C. Steere, and B. T. Huber. 1998. Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science 281:703. <abstract>
  • Heeger, P. S., T. Forsthuber, C. Shive, E. Biekert, C. Genain, H. H. Hofstetter, A. Karulin, and P. V. Lehmann. 2000. Revisiting tolerance induced by autoantigen in incomplete Freund's adjuvant. J. Immunol. 164:5771. <abstract>
  • Herzog, B. A., Ott P. A., Dittrich, M. T., Quast, S., Karulin, A. Y., Kalbacher, H., Karges, W., Tary-Lehmann, M., Lehmann, P. V., Boehm, B. O., Durinovic-Bello I. Increased in vivo frequency of IA-2 peptide-reactive IFNgamma+/IL-4- T cells in type 1 diabetic subjects. J. Autoimmun. 2004 Aug;23(1):45-54. <abstract>
  • Hofstetter, H. H., K. V. Toyka, M. Tary-Lehmann, and P. V. Lehmann. 2007. Kinetics and Organ Distribution of IL-17-Producing CD4 Cells in Proteolipid Protein 139-151 Peptide-Induced Experimental Autoimmune Encephalomyelitis of SJL Mice. J. Immunol. 178:1372. <abstract>
  • Hofstetter, H. H., A. Y. Karulin, T. G. Forsthuber, P. A. Ott, M. Tary-Lehmann, and P. V. Lehmann. 2005. The cytokine signature of MOG-specific CD4 cells in the EAE of C57BL/6 mice. J. Neuroimmunol. 170:105. <abstract>
  • Hofstetter, H. H., O. S. Targoni, A. Y. Karulin, T. G. Forsthuber, M. Tary-Lehmann, and P. V. Lehmann. 2005. Does the frequency and avidity spectrum of the neuroantigen-specific T cells in the blood mirror the autoimmune process in the central nervous system of mice undergoing experimental allergic encephalomyelitis? J. Immunol. 174:4598. <abstract>
  • Hofstetter, H. H., D. L. Sewell, F. Liu, M. Sandor, T. Forsthuber, P. V. Lehmann, and Z. Fabry. 2003. Autoreactive T cells promote post-traumatic healing in the central nervous system. J. Neuroimmunol. 134:25. <abstract>
  • Kaufman, D. L., M. Clare-Salzler, J. Tian, T. Forsthuber, G. S. Ting, P. Robinson, M. A. Atkinson, E. E. Sercarz, A. J. Tobin, and P. V. Lehmann. 1993. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366:69. <abstract>
  • Kuerten, S., F. S. Lichtenegger, S. Faas, D. N. Angelov, M. Tary-Lehmann, and P. V. Lehmann. 2006. MBP-PLP fusion protein-induced EAE in C57BL/6 mice. J. Neuroimmunol. 177:99. <abstract>
  • Lehmann, P. V., E. E. Sercarz, T. Forsthuber, C. M. Dayan, and G. Gammon. 1993. Determinant spreading and the dynamics of the autoimmune T-cell repertoire. Immunol. Today 14:203. <abstract>
  • Lehmann, P. V. 2000. Selective peptidomimetic blockers of autoantigen presentation: a novel therapeutic approach to autoimmune disease. Trends Pharmacol. Sci. 21:79.
  • Lehmann, P. V., O. S. Targoni, and T. G. Forsthuber. 1998. Shifting T-cell activation thresholds in autoimmunity and determinant spreading. Immunol. Rev. 164:53.
  • Lehmann, P. V. 1998. The fate of T cells in the brain: veni, vidi, vici and veni, mori. Am. J. Pathol. 153:677.
  • Lehmann, P. V., T. Forsthuber, A. Miller, and E. E. Sercarz. 1992. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358:155.
  • Meierhoff, G., P. A. Ott, P. V. Lehmann, and N. C. Schloot. 2002. Cytokine detection by ELISPOT: relevance for immunological studies in type 1 diabetes. Diabetes Metab Res. Rev. 18:367.
  • Moldovan, I.R., Rudick, R.A., Cotleur, A.C., Born S.E., Lee, J.C., Karafa, M.T., Pelfrey, C.M. Longitudinal single-cell cytokine responses reveal recurrent autoimmune myelin reactivity in relapsing-remitting multiple sclerosis patients. Mult Scler. 2005 Jun;11(3):251-60. <abstract>
  • Moldovan, I.R., Rudick, R.A., Cotleur, A.C., Born S.E., Lee, J.C., Karafa, M.T., Pelfrey, C.M. Interferon gamma responses to myelin peptides in multiple sclerosis correlate with a new clinical measure of disease progression. J Neuroimmunol. 2003 Aug;141(1-2):132-40. <abstract>
  • Ott, P. A., Dittrich, M. T., Herzog, B. A., Guerkov, R., Gottlieb, P. A., Putnam, A. L., Durinovic-Bello, I., Boehm, B. O., Tary-Lehmann, M., Lehmann, P. V., T cells recognize multiple GAD65 and proinsulin epitopes in human type 1 diabetes, suggesting determinant spreading. J. Clin. Immunol. 2004 Jul;24(4):327-39.
  • Ott, P. A., M. R. Anderson, M. Tary-Lehmann, and P. V. Lehmann. 2005. CD4+CD25+ regulatory T cells control the progression from periinsulitis to destructive insulitis in murine autoimmune diabetes. Cell Immunol. 235:1.
  • Ott, P. A., B. A. Herzog, S. Quast, H. H. Hofstetter, B. O. Boehm, M. Tary-Lehmann, I. Durinovic-Bello, B. R. Berner, and P. V. Lehmann. 2005. Islet-cell antigen-reactive T cells show different expansion rates and Th1/Th2 differentiation in type 1 diabetic patients and healthy controls. Clin. Immunol. 115:102.
  • Pelfrey, C. M., R. A. Rudick, A. C. Cotleur, J. C. Lee, M. Tary-Lehmann, and P. V. Lehmann. 2000. Quantification of self-recognition in multiple sclerosis by single-cell analysis of cytokine production. J. Immunol. 165:1641.
  • Pelfrey, C. M., Moldovan, I. R., Cotleur, A. C., Zamor, N, Rudick, R. A., Effects of sex hormones on costimulatory molecule expression in multiple sclerosis. J Neuroimmunol. 2005 Oct;167(1-2):190-203. <abstract>
  • Pelfrey, C. M., Moldovan I. R., Epitope mapping in multiple sclerosis using the ELISPOT assay. Methods Mol Biol. 2005;302:219-36. <abstract>
  • Radeke, H. H., T. Tschernig, A. Karulin, G. Schumm, S. N. Emancipator, K. Resch, and M. Tary-Lehmann. 2002. CD4+ T cells recognizing specific antigen deposited in glomeruli cause glomerulonephritis-like kidney injury. Clin. Immunol. 104:161.
  • Sercarz, E. E., P. V. Lehmann, A. Ametani, G. Benichou, A. Miller, and K. Moudgil. 1993. Dominance and crypticity of T cell antigenic determinants. Annu. Rev. Immunol. 11:729.
  • Targoni, O. S., J. Baus, H. H. Hofstetter, M. D. Hesse, A. Y. Karulin, B. O. Boehm, T. G. Forsthuber, and P. V. Lehmann. 2001. Frequencies of neuroantigen-specific T cells in the central nervous system versus the immune periphery during the course of experimental allergic encephalomyelitis. J. Immunol. 166:4757.
  • Targoni, O. S., M. Tary-Lehmann, and P. V. Lehmann. 1999. Prevention of murine EAE by oral hydrolytic enzyme treatment. J. Autoimmun. 12:191.
  • Targoni, O. S., and P. V. Lehmann. 1998. Endogenous myelin basic protein inactivates the high avidity T cell repertoire. J. Exp. Med. 187:2055.
  • Tian, J., P. V. Lehmann, and D. L. Kaufman. 1997. Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens. J. Exp. Med. 186:2039
  • Tian, J., M. A. Atkinson, M. Clare-Salzler, A. Herschenfeld, T. Forsthuber, P. V. Lehmann, and D. L. Kaufman. 1996. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J. Exp. Med. 183:1561.
  • Tian, J., M. Clare-Salzler, A. Herschenfeld, B. Middleton, D. Newman, R. Mueller, S. Arita, C. Evans, M. A. Atkinson, Y. Mullen, N. Sarvetnick, A. J. Tobin, P. V. Lehmann, and D. L. Kaufman. 1996. Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice. Nat. Med. 2:1348.
  • Tian, J., P. V. Lehmann, and D. L. Kaufman. 1994. T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele. J. Exp. Med. 180:1979.
  • Tary-Lehmann, M., A. Saxon, and P. V. Lehmann. 1995. The human immune system in hu-PBL-SCID mice. Immunol. Today 16:529.
  • Tary-Lehmann, M., P. V. Lehmann, D. Schols, M. G. Roncarolo, and A. Saxon. 1994. Anti-SCID mouse reactivity shapes the human CD4+ T cell repertoire in hu-PBL-SCID chimeras. J. Exp. Med. 180:1817.