Kuerten, S., F. S. Lichtenegger, S. Faas, D. N. Angelov, M. Tary-Lehmann, and P. V. Lehmann. 2006. MBP-PLP fusion protein-induced EAE in C57BL/6 mice. J. Neuroimmunol. 177:99.

Categories: Autoimmunity

Gene knock-out and knock-in mice are becoming increasingly indispensable for mechanism-oriented studies of EAE. Most gene-modified mice are on the C57BL/6 background, for which presently there are only two EAE models available, the MOG peptide 35-55 and the PLP 178-191 peptide induced disease. However, because MS is not a single pathogenic entity, different EAE models are required to reproduce and study its various features. Here we are introducing MBP-PLP fusion protein (MP4)-induced EAE for C57BL/6 mice. B cell- and CD8(+) T cell-dependence, as well as multi-determinant recognition are among the unique features of this demyelinating EAE.